Osteoarthritis is classified as the most prevalent joint disorder, especially in middle-aged and elderly people, and is therefore seen as one of the ten most disabling diseases in developed countries.1
Current osteoarthritis management strategies focus on pain relief, function improvement, and quality of life maintenance. TRB Chemedica researches, develops, manufactures and markets different molecules to treat osteoarthritis-induced pain such as hyaluronic acid-based products and diacerein. OSTENIL® range consists of sodium hyaluronate-containing products with different formulations and has been developed to improve osteoarthritis patients’ symptoms and joint function after intra-articular injection.2-7 Due to its unique viscoelastic properties, hyaluronic acid has been used for many years as viscosupplement to treat osteoarthritis of the knee via intra-articular injection. Diacerein is an active ingredient to treat osteoarthritis symptoms, which is obtained from Aloe Vera plants. Clinically, diacerein has demonstrated to efficiently relieve pain and improve joint function in patients with knee or hip osteoarthritis.
Relieving painful tendinopathy
Tendinopathies are the most common tendon disorder mainly caused by overuse or inappropriate loading of tendons.10
OSTENIL® TENDON has been developed for the treatment of pain and restricted mobility in tendon disorders. Based on the biomechanical properties of hyaluronic acid, it has demonstrated to be efficacious and safe in treating rotator cuff/supraspinatus tendinopathy11,12, Achilles tendinopathy13,14, tennis elbow13 and peroneal tendinopathy13. Patients will benefit from rapid pain relief and a quick return to normal daily and sport activities. 11-14
Accelerating post-arthroscopy recovery
VISCOSEAL® SYRINGE solution for joint recovery after arthroscopy has been specifically developed to replace the synovial fluid post-arthroscopy and therefore to prevent post-operative complications.15VISCOSEAL®SYRINGE has an excellent safety profile and has demonstrated to:
Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull World Health Organ. 2003; 81(9):646-56
Pons M, Alvarez F, Solana J, Viladot R, Varela L. Sodium hyaluronate in the treatment of hallux rigidus. A single-blind, randomized study. Foot Ankle Int 2007 ;28(1) :38-42
Oliveras-Moreno JM Hernandez-Pacheco E, Oliveras-Quintana T, Infante-Cossio P, Gutierrez-Perez JL. Efficacy and safety of sodium hyaluronate in the treatment of Wilkes stage II disease. J Oral Maxillofac Surg 2008 ; 66 : 2243-46
Dreiser RL, Avouac B, Bardin T. Efficacy of sodium hyaluronate versus hylan G-F 20 in the treatment of tibiofemoral osteoarthritis. Ann Rheum Dis 2012; 71(Suppl 3):584
Tsvetkova E, Denisov L, Shmidt EI, Ryabitseva O, Anikin S. Efficacy and safety of sodium hyaluronate in hip osteoarthritis. A randomised double-blind, lidocaine-controlled, multicentre study with a 12-month follow-up. Ann Rheum Dis 2010 ; 69(Suppl3):281
Borras-Verdera A, Calcedo-Bernal V, Ojeda-Levenfeld J, Clavel-Sainz C. Efficacy and safety of a single intra-articular injection of 2% hyaluronic acid plus mannitol in knee osteoarthritis over a 6-month period. Rev Esp Cir Ortop Traumatol 2012; 56(4): 274-80
Dreiser RL, Avouac B, Bardin T. A 6 Month Trial Evaluating Efficacy of One Intra Articular Injection of 2% Sodium Hyaluronate Versus Hylan G F 20 in the Treatment of Painful Tibiofemoral Osteoarthritis. Ann Rheum Dis 2015; 74(Suppl 2):376
Pelletier JP, Yaron M, Haraoui B, Cohen P, Nahir MA, et al. Efficacy and safety of diacerein in osteoarthritis of the knee: a double-blind, placebo-controlled trial. The Diacerein Study Group. Arthritis Rheum. 2000; 43(10):2339-48
Pavelka K, Trc T, Karpas K, Vítek P, Sedlácková M, et al. The efficacy and safety of diacerein in the treatment of painful osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled study with primary end points at two months after the end of a three-month treatment period. Arthritis Rheum. 2007; 56(12): 4055-64
Lipman K, Wang C, Ting K, Soo C, Zheng Z. Tendinopathy: injury, repair, and current exploration. Drug Des Devel Ther. 2018;12:591-603.
Nestorova R et al. Hyaluronic acid “Ostenil Tendon” in partial thickness tears of the supraspinatus tendon: clinical and sonographic assessment. Osteopros Int. 2014; 25 (Suppl 2). Abstract No : P289
Nestorova R, Rashkov R, Petranova T, Kolarov ZI, Sheytanov I, et al. Effectiveness of hyaluronic acid “Ostenil Tendon” in partial thickness rotator cuff tears of the shoulder. Osteopros Int. 2016; 27 (Suppl 1). Abstract No : P299
Lynen N. Treatment of chronic tendinopathies with peritendinous hyaluronan injections under sonographic guidance – an interventional, prospective, single-arm multicenter study. Orthopädische und Unfallchirurgische Praxis. 2012; 1(10):1-11. German
Lynen N, De Vroey T, Spiegel I, Van Ongeval F, Hendrickx NJ, et al. Comparison of Peritendinous Hyaluronan Injections Versus Extracorporeal Shock Wave Therapy in the Treatment of Painful Achilles’ Tendinopathy: A Randomized Clinical Efficacy and Safety Study. Arch Phys Med Rehabil. 2017 ; 98(1) :64-71
Mathies B. Effects of Viscoseal, a synovial fluid substitute, on recovery after arthroscopic partial meniscectomy and joint lavage. Knee Surg Sports Traumatol Arthrosc. 2006;14(1):32-9.
Villamor A, Lloveras J, Camacho L, Ojeda A, Alonso A, Cami J, et al. Viscoseal aids recovery after arthroscopy – A single blind, randomised, multicentre study. Osteoarthritis Cartilage. 2004;12 (Suppl B):S82. Abstract No.: P200.
Anand S, Singisetti K, Srikanth KN, Bamforth C, Asumu T, Buch K. Effect of sodium hyaluronate on recovery after arthroscopic knee surgery. J Knee Surg. 2016;29(6):502-9.
Thein R, Haviv B, Kidron A, Bronak S. Intra-articular injection of hyaluronic acid following arthroscopic partial meniscectomy of the knee. Orthopedics. 2010;33(10):724.
Chau JY, Chan WL, Woo SB, Cheng SC, Wong TM, Wong TK, et al. Hyaluronic acid instillation following arthroscopic anterior cruciate ligament reconstruction: a double-blinded, randomised controlled study. J Orthop Surg (Hong Kong). 2012;20(2):162-5.
Marcheggiani Muccioli GM, Wykes P, Hundle B, Grassi A, Roatti G, Funk L. Effects of a synovial fluid substitute on early recovery after arthroscopic subacromial decompression of the shoulder. Musculoskelet Surg. 2015;99(2):121-6.
Funk L, Wykes PR. Synovial fluid replacement in arthroscopic shoulder surgery – A randomised, prospective, controlled trial. Osteoarthritis Cartilage. 2004;12(Suppl B):S126-7. Abstract No.: P309.
Hempfling H. Intra-articular hyaluronic acid after knee arthroscopy: a two-year study. Knee Surg Sports Traumatol Arthrosc. 2007;15(5):537-46.
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